Publications

HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion

Chemla Y, Itzhaki O, Melamed S, Weller C, Sade Y, Manich P, Reshef K, Xenidis N, Maliah A, Levy G, Parikh R, Bartok O, Levy O, Tal I, Aziel G, Nissani A, Yunger S, Likonen D, Kliminsky V, Golan T, Capron C, Ace V, Levy R, Rasoulouniriana D, Eyal Z, Barzilay Y, Balaban R, Khateeb A, Khosravi R, Grau A, Ziv T, Greenberg P, Netanely D, Vaknin H, Wu X, Amitay Y, Brenner R, Martínez Gómez JM, Hershkovitz D, Yardeni T, Zemser-Werner V, Kobiler O, Friedmann Y, Bassan D, Shamir R, Eisenbach L, Santana-Magal N, Milyavsky M, Eisenberg G, Keren L, Cohen M, Gur D, Barak B, Lotem M, Sprinzak D, Greenberger S, Fisher D, Besser MJ, Khaled M, Close P, Shapira R, Apcher S, Madi A, Levesque MP, Rapino F, Carmi Y, Parikh S, Samuels Y, Levy C. doi: 10.1016/j.cell.2025.11.020

Myelin, white matter, and social deficits in autism spectrum disorder

Kimchi-Feldhorn O, Sade Nir A and Barak B. doi: 10.4103/NRR.NRR-D-25-00366

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements

Levy G, Rokach M, Fischer I, Kimchi-Feldhorn O, Shoob S, Bar E, Rosenberg T, Bartman J, Parnas H, Grad M, Israel-Elgali I, Sfadia E.G, Trangle S.S, Vainshtein A, Eshed-Eisenbach Y, Jahn O, Siems S.B, Werner H.B, Shomron N, Assaf Y, Peles E, Slutsky I, Marco A and Barak B. doi: 10.4103/NRR.NRR-D-25-00366

Cell-of-origin-specific behavioral deficits in oligodendrocyte-derived glioblastoma

Sher D, Mastandrea I, Brosque A, Levy G, Ironi I, Shapira G, Shomron N, Barak B and Friedmann-Morvinski D. doi: 10.1016/j.celrep.2025.116043

Intersection of mitochondrial dysfunction and myelination: an overlooked aspect in neurodevelopmental disorders

Sade Nir A, Wiener G and Barak B. doi: 10.4103/NRR.NRR-D-24-01025

Long-term excessive alcohol consumption enhances myelination in the mouse nucleus accumbens

Liran M, Fischer I, Elboim M, Rahamim N, Gordon T, Urshansky N, Assaf Y, Barak B and Barak S. doi: 10.1523/JNEUROSCI.0280-24.2025

Shank3 mutation impairs glutamate signaling and myelination in ASD mouse model and human iPSC-derived OPCs

Fischer I, Shohat S, Leichtmann-Bardoogo Y, Nayak R, Wiener G, Rosh I, Shemen A, Tripathi U, Rokach M, Bar E, Hussein Y, Carolin Castro A, Chen G, Soffer A, Schokoroy-Trangle S, Elad-Sfadia G, Assaf Y, Schroeder A, Monteiro P, Stern S, Maoz B and Barak B. doi: 10.1126/sciadv.adl4573

Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome

Bar E, Fischer I, Rokach M, Elad-Sfadia G, Shirenova S, Ophir O, Schokoroy-Trangle S, Okun E, Barak B. doi: 10.1002/glia.24519

Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems

Rokach M, Portioli C, Brahmachari S, Estevão BM, Decuzzi P and Barak B. doi: 10.1016/j.addr.2024.115218

Neuronal Gtf2i deletion alters mitochondrial and autophagic properties 

Nir Sade A, Levy G, Trangle SS, Sfadia GE, Bar E, Ophir O, Fischer I, Rokach M, Atzmon A, Parnas H, Rosenberg T, Marco A, Stein OE & Barak B. doi: 10.1038/s42003-023-05612-5

Deletion of Gtf2i via Systemic Administration of AAV-PHP.eB Virus Increases Social Behavior in a Mouse Model of a Neurodevelopmental Disorder

Ophir O, Levy G, Bar E, Kimchi Feldhorn O, Rokach M, Elad Sfadia G and Barak B. doi: 10.3390/biomedicines11082273

Impaired myelin ultrastructure is reversed by citalopram treatment in a mouse model for major depressive disorder

Israel-Elgali I, Pan H, Oved K, Pillar N, Levy G, Barak B, Carneiro A, Gurwitz D, Shomron N. doi: 10.1016/j.jpsychires.2023.09.012

Hyperbaric Oxygen Therapy alleviates social behavior dysfunction and neuroinflammation in a mouse model for Autism spectrum disorders

Fischer I, Shohat S, Levy G, Bar E, Schokoroy Trangle S, Efrati S and Barak B. doi: 10.3390/ijms231911077

SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism

Ivashko-Pachima Y, Ganaiem M, Ben-Horin-Hazak I, Lobyntseva A, Bellaiche N, Fischer I, Levy G, Sragovich S, Karmon G, Giladi E, Shazman S, Barak B and Gozes I. doi: 10.1038/s41380-022-01603-w

In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and cortical development

Schokoroy Trangle S, Rosenberg T, Parnas H, Levy G, Bar E, Marco A and Barak B. doi: 10.1038/s41380-022-01921-z

Altered White Matter and microRNA Expression in a Murine Model Related to Williams Syndrome Suggests That miR-34b/c Affects Brain Development via Ptpru and Dcx Modulation

Grad M, Nir A, Levy G, Schokoroy Trangle S, Shapira G, Shomron N, Assaf Y and Barak B. doi: 10.3390/cells11010158

Williams syndrome 

Kozel B.A, Barak B, Kim C.A, Mervis C.B, Osborne L.R, Porter M, Pober B.R. doi: 10.1038/s41572-021-00276-z

MyelTracer: A semi-automated software for myelin g-ratio quantification

Kaiser T, Allen H, Kwon O, Barak B, Wang J, He Z, Jiang M and Feng G. doi: 10.1523/ENEURO.0558-20.2021

miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons

Shvarts-Serebro I, Sheinin A, Gottfried I, Adler L, Schottlender N, Ashery U & Barak B. doi: 10.1007/s12031-021-01862-2

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder 

Poleg S, Kourieh E, Ruban A, Shapira G , Shomron N , Barak B and Offen D. doi: 10.1038/s41398-021-01612-3

An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques 

Gong X, Diego D.M, Ting J.T, Kaiser T, Sun X, Bastos A.M, Wimmer R.D, Guo B, Chen Q, Zhou Y, Pruner M, Wu C.W.H, Park D, Deisseroth K, Barak B, Boyden E.S, Miller E.K, Halassa M.M, Fu Z, Bi G, Desimone R and Feng G. doi: 10.1016/j.neuron.2020.03.032

 Postnatal therapeutic approaches in genetic neurodevelopmental disorders

Levy G, Barak B. doi: 10.4103/1673-5374.293133

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods 

Ding J , Adiconis X, Simmons S.K,  Kowalczyk M.S , Hession C.C , Marjanovic N.D, Hughes T.K, Wadsworth M.H , Burks T, Nguyen L.T , Kwon J.Y.H , Barak B , Ge  W , Kedaigle  A.J, Carroll S, Li S, Hacohen N, Rosen O.R, Shalek A.K, Villani A.C, Regev  A, and  Levin  J.Z.  doi: 10.1038/s41587-020-0465-8

Differential excitatory vs inhibitory SCN expression at single cell level regulates brain sodium channel function in neurodevelopmental disorders

Du J, Simmons S, Brunklaus A, Adiconis X,Hession C, Fu Z , Li Y, Shema R, Møller R.S , Barak B, Feng G, Meisler M, Sanders S, Lerche H, Campbell A.J, McCarroll S, Levin J. Z, Lal D. doi: 10.1016/j.ejpn.2019.12.019

Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions 

Fischer I, Barak B. doi: 10.3390/biom10091247

White matter alterations in Williams syndrome related to behavioral and motor impairments

Nir A, Barak B. doi: 10.1002/glia.23868

Microglia roles in synaptic plasticity and myelination in homeostatic conditions and neurodevelopmental disorders

Bar E , Barak B. doi: 10.1002/glia.23637

Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug 

Barak B , Zhang Z, Liu Y, Nir A, Trangle S, Ennis  M, Levandowski K.M, Wang D, Quast K, L. Boulting G.L, Li Y, Bayarsaihan D, He Z  and Feng  G. doi: 10.1038/s41593-019-0380-9

Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum 

Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham I. R. and Feng G. doi: 10.1113/JP275936

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function 

Amal H, Barak B, Bhat V, Gong G, Brian A. Joughin B. A, Wishnok J. S, Feng G, Tannenbaum S. R. doi: 10.1038/s41380-018-0113-6

Neurobiology of social behavior abnormalities in autism spectrum disorders and Williams syndrome 

Barak B and Feng G. doi: 10.1038/nn.4276

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

Chen N, Sugihara H, Kim J, Fu Z, Barak B, Sur M, Feng G and Han W. doi: 10.7554/eLife.18716

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes M, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z and Feng G. doi: 10.1016/j.neuron.2015.11.023

Toll-like receptors as developmental tools that regulate neurogenesis during development: an update

Barak B, Feldman N and Okun E. doi: 10.3389/fnins.2014.00272

Cardiovascular fitness and cognitive spatial learning in rodents and in humans

Barak B, Feldman N and Okun E. doi: 10.1093/gerona/glu162

ER stress-induced eIF2a phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin 

Leitman J, Barak B, Ashery U, Hartl U and Lederkremer GZ. doi: 10.1371/journal.pone.0090803

Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory

Barak B, Okun E, Ben-Simon Y, Wang Y, Norman E, Sheinin A, Pita MA, Yizhar O, Mughal MR, Stuenkel E, van Praag H, Mattson MP and Ashery U. doi: 10.1007/s12017-013-8223-4

Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models 

Barak B, Shvarts-Serebro I, Modai S, Gilam A, Okun E, Michaelson DM, Mattson MP, Shomron N and Ashery U. doi: 10.1038/tp.2013.77

Highly Ordered Large-Scale Neuronal Networks of Individual Cells – Toward single cell to 3D nanowire intracellular interfaces 

Kwiat M, Elnathan R, Pevzner A, Peretz A, Barak B, Peretz H, Ducobni T, Stein D, Mittelman L, Ashery U and Patolsky F. doi: 10.1021/am300602e

Evidence for a Developmental Role for TLR4 in Learning and Memory 

Okun E, Barak B, Saada-Madar R, Rothman SM,  Griffioen KJ, Roberts N, Castro K,  Mughal MR,  Pita MA,  Stranahan AM, Arumugam TV and Mattson MP.  doi: 10.1371/journal.pone.0047522

Tomosyn expression and localization at the sub-areas of the mouse hippocampus

Barak B, Williams A, Bielopolski N, Gottfried I, Okun E, Brown M, Matti U, Rettig J, Stuenkel E and Ashery U. 

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

Okun E, Griffioen K, Barak B, Roberts N, Castro K, Pita M, Cheng A, Mughal M, Wan R, Ashery U and Mattson MP.  doi: 10.1073/pnas.1005807107

Friends and foes in synaptic transmission—the role of Tomosyn in vesicle priming

Ashery U, Bielopolski N, Barak B and Ofer Yizhar.